British Journal of Anaesthesia, 1992, Vol. 69, No. 5 468-470
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia
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IS THE "K-TYPE" CAFFEINE-HALOTHANE RESPONDER SUSCEPTIBLE TO MALIGNANT HYPERTHERMIA ?
The Leeds Malignant Hyperthermia Investigation Unit, Academic Unit of Anaesthesia, St James's University Hospital Leeds LS9 7TF
The "K-type" designation is used to describe a patient being investigated for malignant hyper-thermia (MH) when concurrent administration of caffeine and halothane induces muscle contracture (rigidity, spasm) in vitro, but when halothane and caffeine given separately produce a normal response. It is accepted in some centres that K-type individuals are susceptible to malignant hyper-thermia (MHS). In this paper, the K-type is shown not to correlate with the MH susceptible (MHS) status as accepted by the European MH group.
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