Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (29)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HICKS, R. G.
Right arrow Articles by BURKE, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HICKS, R. G.
Right arrow Articles by BURKE, D. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1992, Vol. 69, No. 2 130-136
© 1992 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

SOME EFFECTS OF ISOFLURANE ON I WAVES OF THE MOTOR EVOKED POTENTIAL

R. G. HICKS, M.SC.1, I. J. WOODFORTH, M.B., B.S., F.F.A.R.A.C.S.2, M. R. CRAWFORD, M.B., B.S., F.F.A.R.A.C.S.1, J. P. H. STEPHEN, M.B., B.S., F.R.A.C.S., F.R.C.S.3 and D. J. BURKE, M.D., D.SC., F.R.A.C.P.1

1Department of Clinical Neurophysiology, The Prince Henry Hospital Little Bay, N.S.W. 2036, Australia
2Department of Anaesthesia, Prince of Wales Hospital Randwick, N.S.W. 2031, Australia
3Department of Orthopaedic Surgery, Prince of Wales Children's Hospital Randwick, N.S.W. 2031

We have investigated the effects of isoflurane anaesthesia on the motor evoked potential recorded in the extradural space during corrective spinal surgery in 15 patients. Isoflurane was added to a nitrous oxide in oxygen mixture supplemented with fentanyl and a neuromuscular blocking agent. Isoflurane was administered to achieve end-tidal concentrations of 2%, 1 % and 0% in all patients, and also of 1.5% and 0.5% in nine patients. Transcranial electrical stimulation of the motor cortex was used to elicit descending volleys in corticospinal axons (the motor evoked potential). With stimuli of 450-750 V and no isoflurane, multiple I waves were always seen following the D wave. In all patients the number of I waves decreased and individual I waves became smaller in amplitude the greater the isoflurane concentration, but there were only minor changes in the D wave. The greatest depressant effect on I waves occurred at an end-tidal concentration of 0.5%. Given that I waves are an index of synaptic transmission, anaesthetic-induced changes in I waves may provide a useful model for the neuronal events underlying anaesthesia-induced unconsciousness.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
M. Brus-Ramer, J. B. Carmel, S. Chakrabarty, and J. H. Martin
Electrical Stimulation of Spared Corticospinal Axons Augments Connections with Ipsilateral Spinal Motor Circuits after Injury
J. Neurosci., December 12, 2007; 27(50): 13793 - 13801.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
V. Rohde, G. A. Krombach, J. H. Baumert, I. Kreitschmann-Andermahr, M. Weinzierl, and J. M. Gilsbach
Measurement of motor evoked potentials following repetitive magnetic motor cortex stimulation during isoflurane or propofol anaesthesia
Br. J. Anaesth., October 1, 2003; 91(4): 487 - 492.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
H. Andel, G.S. Bayer, R. Ciovica, J. Monsivais, M. Basco, M. Zimpfer, and E. Turkof
Depressive effect of isoflurane on motor evoked potentials in the Nubian goat
Can J Anesth, January 1, 2000; 47(1): 81 - 86.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
I. J. Woodforth, R. G. Hicks, M. R. Crawford, J. P. H. Stephen, and D. Burke
Depression of I Waves in Corticospinal Volleys by Sevoflurane, Thiopental, and Propofol
Anesth. Analg., November 1, 1999; 89(5): 1182 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Pereon, J.-M. Bernard, S. N. T. Tich, R. Genet, F. Petitfaux, and P. Guiheneuc
The Effects of Desflurane on the Nervous System: From Spinal Cord to Muscles
Anesth. Analg., August 1, 1999; 89(2): 490 - 490.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. H. Ubags, C. J. Kalkman, H. D. Been, J. H. Koelman, and B. W. O. de Visser
A Comparison of Myogenic Motor Evoked Responses to Electrical and Magnetic Transcranial Stimulation During Nitrous Oxide/Opioid Anesthesia
Anesth. Analg., March 1, 1999; 88(3): 568 - 568.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.