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British Journal of Anaesthesia, 1991, Vol. 67, No. 1 49-53
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DISPOSITION OF PROPOFOL AT CAESAREAN SECTION AND IN THE POSTPARTUM PERIOD

T. GIN, M.B., CH.B., B.SC., F.C.ANAES., F.F.A.R.A.C.S., G. YAU, M.B., B.S., F.C.ANAES., W. JONG, M.B., B.S., F.F.A.R.A.C.S., P. TAN, B.SC.CHEM., R. K. W. LEUNG, M.B., B.S., M.R.C.P. and K. CHAN, PH.D., F.R.PHARM.S., F.C.P., F.I.BIOL., F.A.C.B.

Department of Anaesthesia & Intensive Care, Prince of Wales Hospital, The Chinese University of Hong Kong Shatin, Hong Kong
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong Shatin, Hong Kong
Department of Pharmacology, The Chinese University of Hong Kong Shatin, Hong Kong

We have compared the pharmacokinetics of a bolus dose of propofol 2 mg kg–1 in eight patients undergoing Caesarean section with those in eight postpartum patients undergoing sterilization by mini-laparotomy. The Caesarean section group had a total body clearance of (median) 31.5 (range 24.4–53.3) ml min–1 kg–1, apparent volume of distribution at steady state 5.10 (2.46–6.61) litre kg–1 and mean residence time 161 (52.3–251) min; values for the postpartum group were 33.8 (21.5–47.2) ml min–1 kg–1, 5.17 (3.47–8.09) litre kg–1 and 163 (92.3–238) min, respectively. The 95% confidence interval for the umbilical venous to maternal venous ratio of propofol at delivery was 0.62–0.86. Plasma protein binding studies showed there was less unbound propofol in maternal plasma (1.28–2.29%) compared with umbilical plasma (2.08–3.88%) (P<0.01). Neonatal concentrations of propofol were greater than maternal concentrations at 2 h and were in the range 0.05–0.11 µg ml–1 at 4h.


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