British Journal of Anaesthesia, 1991, Vol. 67, No. 1 41-48
© 1991 The Board of Management and Trustees of the British Journal of Anaesthesia
research-article |
PHARMACOKINETIC MODEL DRIVEN INFUSION OF PROPOFOL IN CHILDREN
Division of Anaesthetics, Glasgow Royal Infirmary 8–16 Alexandra Parade, Glasgow G31 2ER
University Department of Anaesthetics, Glasgow Royal Infirmary 8–16 Alexandra Parade, Glasgow G31 2ER
Division of Anaesthetics, Royal Hospital for Sick Children Glasgow
Correspondence to M.W.
A computer controlled infusion device for propofol was used to induce and maintain general anaesthesia in 20 children undergoing minor surgical procedures. The device was programmed with an adult pharmacokinetic model for propofol. During and after anaesthesia, blood samples were taken for measurement of propofol concentrations and it was found that the values obtained were systematically over-predicted by the delivery system algorithm. New pharmacokinetic microconstants were derived from our data which reflected more accurately the elimination and distribution of propofol in a prospective study involving another 10 children.
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