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British Journal of Anaesthesia, 1990, Vol. 64, No. 1 67-71
© 1990 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

AN OPEN STUDY OF ROPIVACAINE IN EXTRADURAL ANAESTHESIA

E. WHITEHEAD, B.SC., F.F.A.R.C.S., B. ARRIGONI, F.F.A.R.C.S. and J. BANNISTER, F.F.A.R.C.S.

Department of Anaesthetics, St Thomas' Hospital Lambeth Palace Road, London SE1 7EH
Department of Anaesthesia, Charing Cross Hospital London
Department of Anaesthesia, The Royal Infirmary Edinburgh

Correspondence to E.W.

Ropivacaine 0.5%, 0.75% and 1.0% was investigated in an open study of extradural anaesthesia in three groups of 15 patients undergoing urological or orthopaedic surgery. Following a test dose of 3 ml of 1.0% lignocaine with 1:200 000 adrenaline, ropivacaine 20 ml was given in incremental doses over 4 min via a lumbar extradural catheter. The onset time for analgesia was short in all groups: T12 was blocked 4–6 min after the end of the injection of ropivacaine. The maximum segmental level was significantly higher in the 0.75% and the 1.0% groups (T2) than in the 0.5% group (T5). Complete motor block was obtained in seven, four and nine patients in the 0.5%, 0.75% and the 1.0% groups, respectively. Duration of algesia increased with increasing concentration of ropivacaine: mean duration of analgesia was 203 and 266 min at T10 and 253 and 314 min at L5 for the 0.5 and 1 % solutions, respectively. Mean duration of complete motor block was 94 and 192 min for the same solutions. Analgesia was satisfactory for surgery in all patients except for one in the 0.75% group. Hypotension was experienced by three, seven and three patients in the 0.5%, 0.75% and 1.0% groups, respectively. Bradycardia occurred in seven patients and was associated with hypotension in five. Backache was experienced after operation by four patients, and three patients complained of a brief mild headache. No late adverse events were seen.


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