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British Journal of Anaesthesia, 1989, Vol. 62, No. 1 54-60
© 1989 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PROPOFOL FOR INDUCTION AND MAINTENANCE OF ANAESTHESIA: COMPARISON BETWEEN YOUNGER AND OLDER PATIENTS

G. L. SCHEEPSTRA, M.D., L. H. D. J. BOOIJ, M.D., PH.D., C. L. G. RUTTEN, M.D. and L. G. J. COENEN, M.D.

Free University Hospital P.O. Box 7057, 1007 MB Amsterdam, The Netherlands

Correspndence to G.L.S.

The propofol requirements for the induction and maintenance of anaesthesia were compared in groups of younger and older patients. Side effects, influence on the cardiovascular system and recovery times were compared between 20 unpremedicated ASA I–III, 25–40-yr-old patients and 20 65–80-yr-old patients all scheduled to undergo elective surgery. After induction with propofol, anaesthesia was maintained with a continuous infusion of the drug. Vecuronium and fentanyl were administered as required. In the young group propofol 2.2 mg kg–1 and in the elderly 1.7 mg kg–1 were needed for induction (P < 0.05). The maintenance doses were 10.0 mg kg–1 h–1 and 8.6 mg kg–1 h–1, respectively (P < 0.01). Side effects were more pronounced in the younger patients. Influences on the cardiovascular system were definite, but mild. The younger patients awoke sooner: 7.8 v. 14.3 min (P < 0.01) after the discontinuation of the infusion of propofol.


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