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British Journal of Anaesthesia, 1988, Vol. 61, No. 3 345-346
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECTS OF NADOLOL ON ARRHYTHMIAS DURING LAPAROSCOPY PERFORMED UNDER GENERAL ANAESTHESIA

J. M. A. BURNS, M.B., CH.B., M.R.C.P. (U.K.), D. M. HART, M.D., F.R.C.S. (GLASG.) F.R.C.O.G., R. L. HUGHES, M.D., F.R.C.P., F.F.A.R.C.S., A. W. KELMAN, PH.D. and W. S. HILLIS, M.B., CH.B., F.R.C.P. (GLASG.)

Department of Materia Medica Stobhill General Hospital, Balornock Road, Glasgow G21 3UW
Department of Gynaecology Stobhill General Hospital, Balornock Road, Glasgow G21 3UW
Department of Anaesthesia Stobhill General Hospital, Balornock Road, Glasgow G21 3UW

Cardiac arrhythmias are a well recognized complication of anaesthesia for laparoscopy. The effect of nadolol, given by mouth 12 h before operation, was compared with placebo on arrhythmias in 86 females undergoing laparoscopy. All types of arrhythmia were documented; there was a 97% incidence in the placebo group, but in the nadolol group there was a smaller incidence of supraventricular tachycardia, ventricular ectopics and atrioventricular dissociation (P < 0.01). There was no significant difference in the incidence of sinus bradycardia. Nadolol may be recommended as a safe agent to be given by mouth before laparoscopy to reduce the frequency of cardiac arrhythmias during anaesthesia.


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