Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by SEMPLE, A. J.
Right arrow Articles by GRANT, I. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SEMPLE, A. J.
Right arrow Articles by GRANT, I. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1988, Vol. 60, No. 6 632-638
© 1988 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

EFFECT OF THE ADDITION OF ADRENALINE TO EXTRADURAL DIAMORPHINE ANALGESIA AFTER CAESAREAN SECTION

A. J. SEMPLE*, D. J. MACRAE, S. MUNISHANKARAPPA, L. M. BURROW, M. K. MILNE and I. S. GRANT

A. J. SEMPLE, F.F.A.R.C.S; D. J. MACRAE B.M.SC, F.F.A.R.C.S; S. MUNISHANKARAPPA, M.B. CH.B., D.A.; L. M. BURROW, M.SC, M.P.S.; M. K. MILNE, D.OBST.R.C.O.G., F.F.A.R.C.S.; I. S. GRANT, F.R.C.P., F.F.A.R.C.S.I.; Departments of Anaesthesia and Pharmacy, Ninewells Hospital and Medical School, Dundee DD1 9SY.

In a randomized double-blind study the effect of the addition of adrenaline to extradural dia-morphine was assessed in 54 patients after Caesarean section. Patients received extradural diamorphine 5 mg in saline 10 ml with or without adrenaline 1 in 200 000 for postoperative pain relief. Analgesia was profound and of rapid onset in both groups. Duration of analgesia was greater in the adrenaline group (time to next analgesia 12.51 ± 0.94 h, mean ± SEM), than in the saline group (9.87 ± 0.98 h) (P = 0.057). Analgesia was also more consistent in the adrenaline group, with 77% of patients having more than 8 h of good analgesia compared with 48% in the saline group (P < 0.05). Plasma morphine concentrations, measured in 12 patients, were lower, although not significantly so, in the adrenaline group and mean time to peak concentration markedly delayed. No serious side effects were observed, but there was a higher incidence of vomiting in the adrenaline group.

*Present address: Department of Anaesthesia, Brompton Hospital, Fulham Road, London SW3 6HP.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
M. Curatolo
Is Epinephrine Unfairly Neglected for Postoperative Epidural Mixtures?
Anesth. Analg., June 1, 2002; 94(6): 1381 - 1383.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.