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British Journal of Anaesthesia, 1986, Vol. 58, No. 4 447-450
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

SUXAMETHONIUM CHLORIDE AND MALIGNANT HYPERPYREXIA

G. J. GALLOWAY, B.SC.(HONS.), PHD.* and M. A. DENBOROUGH, M.D., D.PHIL., D.SC., F.R.C.P., F.R.A.C.P.

Department of Medicine and Clinical Science, The John Curtin School of Medical Research, The Australian National University Canberra, ACT 2600, Australia

Pure suxamethonium chloride does not produce in vitro contracture of skeletal muscle from swine which are susceptible to malignant hyperpyrexia (MH), but does induce MH in vivo. It is suggested that suxamethonium chloride induces MH because the fasciculations which it causes lead to an increase in the myoplasmic calcium concentration.

*Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU.


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