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British Journal of Anaesthesia, 1986, Vol. 58, No. 4 444-446
© 1986 The Board of Management and Trustees of the British Journal of Anaesthesia

other

THE SCREENING OF ATRACURIUM IN MHS SWINE

D. F. MORRELL, F.F.A.(S.A.) and G. G. HARRISON, M.D., F.F.A.R.C.S.(ENG.)

Department of Anaesthetics, University of Cape Town and Groote Schuur Hospital, Medical School Observatory 7925, South Africa

The potential role of atracurium besylate as a trigger or attenuator of the malignanthyperthermia syndrome was tested in six MHS Landrace swine. Animals were tested for susceptibility and then exposed to atracurium given as an i.v. bolus both alone and concomitantly with 2% halothane. In no instance could the syndrome be triggered by atracurium nor did it convincingly attenuate the syndrome when triggered by halothane.


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