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British Journal of Anaesthesia, 1985, Vol. 57, No. 9 872-876
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

PHARMACOKINETICS OF PHENOPERIDINE IN ANAESTHETIZED PATIENTS UNDERGOING GENERAL SURGERY

M. FISCHLER, M.D, J. C. LEVRON, M.D, H. TRANG, M.D, J. F. VAXELAIRE, B. FLAISLER and G. VOURC'H, M.D.,F.F.A.R.CS

Service d'Anesthesie, Centre Medico-Chirurgical Foch 40 rue Worth, 92151 Suresnes,France
Laboratoire Janssen-LeBrun, Paris, France

Correspondence to M. F.

The pharmacokinetics of phenoperidine have been studied in five anaesthetized patients receiving a 2-mg bolus dose i.v. Plasma concentrations were measured using a sensitive radioimmunoassay method. The distribution of phenoperidine was described according to a two-compartment open model. The mean distribution half-life (T1/2{alpha}) for the five patients was short (2.2 min); the mean elimination half-life (T1/2ß) was 193 min. The mean whole body clearance was 22 ml min-1 kg-1 and the apparent steady state distribution volume (VSS) was 5.7 litre kg-1. Secondary concentration peaks occurred in all patients; in two patients these were substantial and occurred 80 min after injection.


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