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British Journal of Anaesthesia, 1985, Vol. 57, No. 2 214-219
© 1985 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

CHRONOTROPIC AND DROMOTROPIC EFFECTS OF ATROPINE AND HYOSCINE METHOBROMIDE IN UNANAESTHETIZED DOGS

J. P. KANTELIP, M.D., M. ALATIENNE, M.D., G. GUEORGUIEV, M.D. and P. DUCHENE-MARULLAZ, M.D.

Laboratoire de Pharmacologie Médicale Inserm U195, Faculté de Médecine, 63001 Clermont-Ferrand Cédex, France
Faculty of Medicine Plovdiv, Bulgaria

Atrial pacing at progressively increasing frequencies was performed in 12 awake dogs through electrodes implanted aseptically in the right atrium and led out through the skin of the neck. Heart rate and the Wenckebach point (the minimum pacing frequency for which a second degree A-V block first appeared) were measured by electrocardiography. The responses of the sinc-atrial and auriculo-ventricular nodes to atropine and hyoscine methobromide were characteristically bimodal. Slowing of the heart rate and atrioventricular conduction appeared with the lower doses of atropine (6.25 µg kg–1 i.v) and hyoscine methobromide (0.4 µg kg–1 i.v.); at doses of atropine 12.5 µg kg–1 i.v. and hyoscine methobromide 1.56 µ kg–1 i.v., onlyatrioventricular conduction was slowed; an acceleration of heart rate and atrioventricular conduction occurred in response to the higher doses of both drugs. These results show, in the awake dog, that the effects of atropine and hyoscine methobromide on heart rate and atrioventricular conduction are entirely comparable when appropriate doses are used, and reveal a difference in the responsiveness of the sino-atrial and auriculo-ventricular nodes to these drugs.


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