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British Journal of Anaesthesia, 1984, Vol. 56, No. 6 631-636
© 1984 The Board of Management and Trustees of the British Journal of Anaesthesia

other

HYPOXIC VENTILATORY DRIVE IN THE DOG UNDER ALTHESIN ANAESTHESIA

J. H. GAUDY, S. BERGERET, J. F. BOITIER and F. FERRACCI

Laboratoire d'Anesthésiologie, Höspital Rothschild 33, boulevard de Pipus, 75012 Paris, France

* Address for correspondence: Service de Réanimation Chirurgicale Polyvalente, Hôpital Rothschild, 33 bd de Picpus, 75012 Paris, France.

Althesin was administered i.v. to eight dogs, using two different rates of infusion (6.55 +mn; 2.13 µl kg–1 min and 12.80 +mn; 2.00 µl kg–1 min). Ventilation (TI, TE, RR, TI/Ttot, VT, VE, VT/TI) and arterial blood-gas tensions were measured in air and during a 10-min period of 100% oxygen breathing. For both rates of Althesin infusion the ventilatory response to oxygen was identical: there was significant depression of ventilation (decrease in VE and of the ventilatory drive, VT/TI) from the 1st min of inhalation lasting up to the 10th min. This decrease in ventilation was more marked and persistent than the decrease noticed in the unanaesthetized dog. We conclude that the hypoxic ventilatory drive persists in the dog under Althesin anaesthesia.


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