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British Journal of Anaesthesia, 1984, Vol. 56, No. 10 1139-1142
© 1984 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

COMPARISON OF SOME PHARMACOLOGICAL PROPERTIES OF 4-AMINOPYRIDINE AND 3,4-DIAMINOPYRIDINE IN VIVO

T. HOUSTON, M.B., CH.B., F.F.A.R.C.S and B. J. PLEUVRY, B.PHARM., M.SC, PH.D.

Departments of Anaesthesia and Pharmacology, University of Manchester Manchester

Correspondence to B.J.P

4-Aminopyridine and 3,4-diaminopyridine have been compared with respect to their interactions with morphine in the mousein vivo. In contrast to 4-aminopyridine, 3,4-diaminopyridine was capable of reducing morphine-induced respiratory rate depression in doses which did not produce signs of toridty.


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