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British Journal of Anaesthesia, 1984, Vol. 56, No. 10 1109-1112
© 1984 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

SEDATION FOR ENDOSCOPY: A COMPARISON BETWEEN DIAZEPAM, AND DIAZEPAM PLUS PETHIDINE WITH NALOXONE REVERSAL

D. A. R. BOLDY, M.B., B.CHIR., M.R.C.P.(U.K.){dagger}, J. S. C. ENGLISH, M.B., B.S., M.R.C.P.*, G. S. LANG, M.B., B.S.,M.R.C.P and A. M. HOARE, M.D., M.R.C.P.

{dagger}Department of Medicine, Dudley Road Hospital, Dudley Road, Birmingham B18
*Department of Dermatology, Western Infirmary, Glasgow G116NT
Department of Medicine, Wycombe General Hospital, High Wycombe, Buckinghamshire HP11 2TT

The combination of diazepam plus pethidine, reversed with naloxone, was compared in a double-blind randomized study with diazepam alone in 100 patients undergoing endoscopy. Patients accepted both methods of sedation equally well. There was no significant difference in sedation after endoscopy, but the addition of pethidine produced a significant improvement in patient co-operation during the endoscopy (P< 0.001)


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