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British Journal of Anaesthesia, 1983, Vol. 55, No. 8 779-782
© 1983 The Board of Management and Trustees of the British Journal of Anaesthesia


research-article

VENOUS COMPLICATIONS OF TWO DIAZEPAM PREPARATIONS RELATED TO SIZE OF VEIN

D. F. MARTIN, M.B., M.R.C.P*, and D. E. F. TWEEDLE, CH.M., F.R.C.S

Department of Medicine, University Hospital of South Manchester Manchester
Department of Surgery, University Hospital of South Manchester Manchester

The venous complications associated with the administration of two preparations of diazepam, an aqueous (Valium) or a lipid (Diazemuls) preparation were investigated in 100 panents before upper gastrointestinal endoscopy in a double-blind randomized study. No differences in pain during injection or subsequent thrombophlebitis were found when a large vein was used for the injections. In a retrospective study of 78 patients who had received either preparation in a vein on the dorsum of the hand, the frequency of thrombophlebitis was significantly less with the lipid preparation. Both preparations provided effective sedation for endoscopy.

*Department of Radiology


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