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British Journal of Anaesthesia, 1982, Vol. 54, No. 11 1235-1236
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

other

PARENTERAL RANITIDINE: ONSET AND DURATION OF ACTION

H. G. DAMMANN, M D, P. MÜLLER, M.D and B. SIMON, M.D

Medizinische Universiátsklinik Hamburg Martinistrasse 52, 2000 Hamburg 20, F.R.G.
Medizinische Universitatsklinik Heidelberg Bergheimerstr. 58, 6900 Heidelberg, F.R.G

Ranitidine 50 mg or an equivalent volume of 0.9% saline were given i.v. to 12 healthy volunteers. pH and volumes of the gastric aspirate were measured at intervals. In all subjects ranitidine provoked a rapid and sustained increase in pH and a concomitant reduction of volume secretion when compared with control.


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