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British Journal of Anaesthesia, 1982, Vol. 54, No. 11 1231-1234
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

other

INFLUENCE OF ORAL ATROPINE OR HYOSCINE ON THE ABSORPTION OF ORAL DIAZEPAM

S. M. GREGORETTI, M D* and D. R. A. UGES, PHARM.D

Departments of Anaesthesia and Pharmacy, University Hospital, State University of Groningen Oostersingel 59, 9700 RB Groningen, The Netherlands

The influence of oral atropine or hysocine on the absorption of oral diazepam administered at the same time was studied in eight volunteers using a three-way crossover randomized double-blind design. No difference was found in the timing of sedation or in the degree of sedation after diazepam alone or in combination with the anucholinergks Diazepam serum concentrations were not significantly different after the three regimens. It is concluded that the anticholinergics can be given with diazepam for oral premedication without interfering with diazepam absorption.

*Present address: Department of Anaesthesia, St Radboud-ziekenhuis, Catholic University, 6500 HB Nijmegen, The Netherlands.


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