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British Journal of Anaesthesia, 1982, Vol. 54, No. 11 1217-1221
© 1982 The Board of Management and Trustees of the British Journal of Anaesthesia

other

MYONEURAL ACTIONS OF ORG NC 45

T. A. TORDA, M.D., F F.A.R.A.C.S* and N. KILOH, M.B , B.S., F F.A.R.A C.S

Department of Anaesthesia and Resuscitation, School of Surgery, University of New South Wales
School of Physiology and Pharmacology, University of New South Wales

*Present address for correspondence: T. A. Torda, Department of Anaesthesia and Intensive Care, Prince Henry Hospital, Sydney, N.S.W., 2036, Australia.

In the toad sartorius preparation Org NC 45 reduced the mean quanta] content of the end-plate potential both in magnesium and tubocuraine-treated preparations, as well as blocking post-junctional receptors. In a concentration which permits recording of the miniature end-plate current no channel block was demonstrated.


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