Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MATTILA, M. A. K.
Right arrow Articles by PEKKOLA, P. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MATTILA, M. A. K.
Right arrow Articles by PEKKOLA, P. O.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1269-1272
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

DIAZEPAM IN RECTAL SOLUTION AS PREMEDICATION IN CHILDREN, WITH SPECIAL REFERENCE TO SERUM CONCENTRATIONS

M. A. K. MATTILA, M.D., M. K. RUOPPI, M.D., E. AHLSTRÖM-BENGS, H. M. LARNI, M.I. and P. O. PEKKOLA, M.D.

Department of Anaesthesiology, Kuopio University Hospital SF-70210 Kuopio 21, Finland

Correspondence to M.A.K.M.

The absorption of rectal diazepam solution was studied in 22 children aged 1–9 yr by measuring serum concentrations. The mean dose was 0.27±0.09mg kg–1. The mean serum concentration was 98.5±53.5 ng ml–1 4min after administration and 206.7±105.8ng ml–1 at 11 min. The correlation between dose and scrum concentration was statistically significant at both times. With a dose of 0.4–0.5 mg kg–1 an adequate serum concentration was achieved within 5–6 min. No side-effects were observed. A rectal solution provides a faster, more effective and reliable alternative to tablets and suppositories, and to the uncertain i.m. injection of diazepam. Meticulous nursing is important.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.