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British Journal of Anaesthesia, 1981, Vol. 53, No. 12 1265-1268
© 1981 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

REDUCTION OF VENOUS SEQUELAE OF I.V. DIAZEPAM WITH A FAT EMULSION AS SOLVENT

M. A. K. MATTILA, M.D., M.-L. ROSSI, M. K. RUOPPI, M.D., M. KORHONEN, M.D., H. M. LARNI, M.I. and S. KORTELAINEN

Departments of Anaesthesiology and Gynaecology and Obstetrics, University Hospital Kuopio, Finland

Correspondence to M.A.K.M., Department of Anaesthesiology, University Hospital, SF-70210 Kuopio 21, Finland.

Venous sequelae were studied in 93 female patients undergoing minor gynaecological procedures. They were premedicated with diazepam i.v. dissolved in a fat emulsion (Diazemuls) injected to a superficial vein of the right hand. The patients observed the site of injection for 14 days and recorded their findings. Twenty-eight per cent reported mild tenderness and 7.5% mild or moderate swelling of short duration. Signs of thrombophlebitis were found in 2.2%. Thrombophlebitis after injection can be prevented effectively and safely using fat emulsion as a solvent for diazepam.


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