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British Journal of Anaesthesia, 1979, Vol. 51, No. 5 435-438
© 1979 The Board of Management and Trustees of the British Journal of Anaesthesia

other

EFFECTS OF AGEING ON THE PHARMACOKINETICS OF PANCURONIUM

K. MCLEOD, M.B., CH.B., F.F.A.R.C.S., C. J. HULL, M.B., B.S., F.F.A.R.C.S. and M. J. WATSON, B.SC., PH.D.

Department of Anaesthesia, University of Newcastle upon Tyne
Department of Clinical Biochemistry, University of Newcastle upon Tyne

Correspondence to C. J. Hull

The effects of age on the pharmacokinetics of pancuronium were investigated. The distribution volume of pancuronium did not appear to be age-dependent, but elimination of the drug decreased with increasing age. The clinical implications of these findings are discussed.

*Present address: Toowoomba General Hospital, Toowoomba, Queensland, Australia


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