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British Journal of Anaesthesia, 1979, Vol. 51, No. 5 431-434
© 1979 The Board of Management and Trustees of the British Journal of Anaesthesia

other

ACUTE AND SUBCHRONIC NEUROMUSCULAR BLOCKING CHARACTERISTICS OF STREPTOMYCIN: A COMPARISON WITH NEOMYCIN*

C. LEE, M.D. and A. J. C. DESILVA, M.B., B.S., F.F.A.R.C.S.

Department of Anesthesiology, UCLA School of Medicine Los Angeles, California 90024, U.S.A.

The characteristics of the neuromuscular block produced by streptomycin in vivo were studied on the sciatic-tibialis anterior nerve-muscle preparation of eight anaesthetized cats. The lungs of the animals were ventilated mechanically and normocarbia was maintained. During acute exposure to streptomycin (within 2 h), ED50 for blockade of the twitch was 56 (SEM ± 5) mg kg–1 of the base. The characteristics of block were similar to those of neomycin-induced block in some aspects. There was absence of train-of-four fade and tetanic fade, partial sparing of the responses elicited at 10 Hz and 20 Hz, and total sparing of the 50 Hz tetanus, as well as the post-tetanic twitch. In contrast to neomycin-induced neuromuscular block, however, post-tetanic exhaustion was not observed and prolonged exposure to streptomycin (22–28 h) did not change the characteristics of the block. We conclude that, despite their chemical similarities, streptomycin and neomycin block neuromuscular transmission differently.

*An abstract was presented at the 1978 Annual Meeting of the American Society of Anesthesiologists, October 1978, under the title "Antibiotic-induced neuromuscular block: phenomenological differences between streptomycin and another aminoglycoside neomycin".


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