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British Journal of Anaesthesia, 1971, Vol. 43, No. 7 637-643
© 1971 The Board of Management and Trustees of the British Journal of Anaesthesia

other

RESPIRATORY AND HYPNOTIC EFFECTS OF NITRAZEPAM, DIAZEPAM AND PENTOBARBITONE AND THEIR SOLVENTS IN THE RABBIT AND THE MOUSE

ELIZABETH G. BRADSHAW* and BARBARA J. PLEUVRY

Research Department of Anaesthesia and Pharmacology, University of Manchester
*Present address: Department of Anaesthetics, Royal Infirmary, Glasgow, Q4

Nitrazepam and diazepam only cause significant depression of respiratory rate and loss or righting reflex, in mice, at lethal doses. In sub-lethal doses they induce a stage of deep but rousable sleep which is quite distinct from the intermittent dozing of control mice and the comatose state of mice injected with pentobarbitone. However, the respiratory effects of nitrazepam and diazepam in high doses in mice and low doses in rabbits are modified by the presence of solvent. Furthermore the solvent itself causes a loss of righting reflex in mice and the lethal dose of nitrazepam and diazepam is greatly reduced when the drugs are administered in solvent


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