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British Journal of Anaesthesia, 1966, Vol. 38, No. 5 394-400
© 1966 The Board of Management and Trustees of the British Journal of Anaesthesia

research-article

THE USE OF TACRINE AND SUXAMETHONIUM IN ANAESTHESIA FOR CAESAREAN SECTION

ISOBEL SPEIRS

Department of Anaesthetics, Glasgow Royal Infirmary and Glasgow Royal Maternity Hospital Scotland

Suxamethonium was combined with tacrine to obtain muscle relaxation in anaesthesia for Caesarean section in fifty patients. The mean total dose of suxamethonium used was 60 mg as against 400 mg in thirty patients not given tacrine. The mean duration of muscle paralysis following suxamethonium 25 mg with tacrine 20 mg was 14 minutes compared with 5.5 minutes after suxamethonium 50 mg alone. Postoperative respiratory insufficiency of a mild degree occurred in one patient. Tacrine was found in specimens of urine from each of six neonates. Serious side effects in mother or child were not observed and this combination of drugs was thought worthy of further study for Caesarean section.


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