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British Journal of Anaesthesia 2009 102(2):153-155; doi:10.1093/bja/aen354
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2009. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Capsaicin receptor antagonists: a promising new addition to the pain clinic

The first 10% of the full text of this article appears below.

Capsaicin is the pungent vanilloid found in chilli peppers. Sensitivity to this substance has been used for many years to identify nociceptive fibres. These are predominantly unmyelinated C fibres with slow conduction velocity but also a small number of myelinated A{delta} fibres. The cell bodies of these fibres lie in the dorsal root and trigeminal ganglia. The latter is involved in the pathogenesis of migraine. It is now well established that capsaicin activates a specific member of the transient receptor potential ligand-gated ion channel family, TRPV1 (previously known as the vanilloid receptor, VR1). The endogenous activators for this receptor are noxious heat (>43°C), protons (acidosis, pH 5–6), the endocannabinoid anandamide, and . . . [Full Text of this Article]

Declaration of Interest

D. G. Lambert

Department of Cardiovascular Sciences (Pharmacology and Therapeutics Group)
Division of Anaesthesia, Critical Care and Pain Management
University of Leicester
Leicester Royal Infirmary
Leicester LE1 5WW
UK

E-mail: dgl3@le.ac.uk


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