© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Genetic polymorphisms in the cytochrome P450 system and efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting
| The first 150 words of the full text of this article appear below. |
Postoperative nausea and vomiting (PONV) is a frequent and distressing complication of anaesthesia and surgery with an average incidence ranging between 20% and 30%, but up to 80% in high-risk groups.1 PONV may result in further complications including dehydration, electrolyte imbalance, suture tension and dehiscence, venous hypertension, bleeding, and aspiration.2 In a preoperative survey,3 101 patients were asked to rank 10 possible postoperative outcomes from their most undesirable to their most desirable outcome. Postoperative vomiting was ranked as the most undesirable, nausea as the fourth most undesirable outcome, and pain ranked third in the survey.
The aetiology of PONV is multifactorial involving patient, surgical, and anaesthesia-related factors. On the basis of two independent studies, Apfel and colleagues1 developed a simplified risk score for predicting PONV in adult patients undergoing anaesthesia and surgery. They found that female gender, non-smoking status, history of motion sickness, and postoperative use of opioids are the
Department of Neuroanaesthesia
2091, The Neuroscience Centre
Copenhagen University Hospital
Rigshospitalet
Copenhagen
Denmark
* E-mail: memosu@stud.ku.dk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Diemunsch, G. P. Joshi, and J.-F. Brichant Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting Br. J. Anaesth., July 1, 2009; 103(1): 7 - 13. [Abstract] [Full Text] [PDF]
|
|