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British Journal of Anaesthesia 2008 100(6):857-859; doi:10.1093/bja/aen110
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Unexpected awakening from anaesthesia after hyperstimulation of the medial thalamus in the rat

P. J. Stienen, H. van Oostrom and L. J. Hellebrekers*

Utrecht, The Netherlands

* E-mail: l.j.hellebrekers@uu.nl

The first 10% of the full text of this article appears below.

Editor—We would like to attract the attention of anaesthetists and neurophysiologists to a case in which rats unexpectedly and transiently awoke from anaesthesia during a stereotaxic procedure performed as a part of an experimental lesional study. In our opinion, this important observation, described below, further contributes to the current knowledge on the functional mechanisms underlying the induction and maintenance of anaesthetic-induced unconsciousness.

The stereotaxic procedure served as the initial intervention for the study into the role of thalamic activity in EEG scalp-recordings and incorporated ibotenic acid (IBO)-induced lesions of different thalamic regions. The protocol . . . [Full Text of this Article]


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