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British Journal of Anaesthesia 2008 100(6):856-857; doi:10.1093/bja/aen109
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Nephrotoxicity of hydroxyethyl starch solution

F. M. Brunkhorst* and M. Oppert

Jena and Berlin, Germany

* E-mail: frank.brunkhorst@med.uni-jena.de

The first 10% of the full text of this article appears below.

Editor—Delayed graft function (DGF) after transplantation of cadaver kidneys is associated with poorer subsequent graft survival.1 Fluid management during the donor operation can significantly modify the risk of DGF. Thus, in a blinded randomized trial of 69 kidney transplants from brain-dead donors,2 volume loading with a mean of 2100 ml hydroxyethyl starch (HES) increased the incidence of DGF (P=0.029). In the subset of patients with renal biopsies, osmotic nephrosis-like lesions were observed among all HES recipients, but none of the control group. Such lesions are consistent with HES deposition in renal tissue and have been found to persist as long as 10 yr after HES exposure.3 In a recent study of 262 consecutive brain-dead donors, . . . [Full Text of this Article]

M. Leone*, V. Blasco, J. Albanèse and C. Martin

Marseille, France

* E-mail: marc.leone@ap-hm.fr


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