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British Journal of Anaesthesia 2008 100(5):727-728; doi:10.1093/bja/aen064
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Does placental lactate production have a role in ephedrine-induced fetal metabolic acidosis?

D. Cooper*, S. Sharma, P. Orakkan and U. Franke

Middlesborough, UK

* E-mail: drdavidcooper@aol.com

The first 10% of the full text of this article appears below.

Editor—Maternal ephedrine administration can cause fetal respiratory acidosis during spinal anaesthesia for caesarean section. We consider this to be secondary to a beta-adrenergic-mediated increase in fetal carbon dioxide production.1 Ephedrine can also cause fetal metabolic acidosis. We have previously considered this to be secondary to ephedrine increasing fetal metabolic rate to the extent that oxygen demand exceeds its limited supply, thereby increasing anaerobic metabolism. However, observations from an . . . [Full Text of this Article]


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