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British Journal of Anaesthesia 2007 99(6):772-774; doi:10.1093/bja/aem330
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Forty years of closing volume

The first 10% of the full text of this article appears below.

The fundamental features of ‘airway closure’ were described in a landmark paper by Dollfuss and colleagues,1 published 40 years ago in 1967. This paper showed a tracing of exhaled gas composition, related to lung volume. The subject first exhaled to residual volume and then inhaled a small quantity of an insoluble gas, followed by normal air, filling the lungs to total lung capacity (TLC). In the following slow expiration, the expected alveolar plateau showed an inflexion, with an increase in the tracer gas concentration as lung volume approached the end of expiration, that is, residual volume. The interpretation was that the lung emptied unevenly. The change in tracer gas concentration indicated that the final part of the exhaled gas came from parts of the lung that had received more of the initial inspirate: the principle of ‘first . . . [Full Text of this Article]

G. B. Drummond1,* and J. Milic-Emili2

1 Department of Anaesthesia
Critical Care and Pain Medicine
University of Edinburgh
51 Little France Crescent
Edinburgh EH16 4SA
UK
2 Meakins-Christie Laboratories
McGill University
Montreal
PQ
Canada

* E-mail: g.b.drummond@ed.ac.uk


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