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British Journal of Anaesthesia 2007 99(1):143-144; doi:10.1093/bja/aem151
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Lack of renoprotective effect of i.v. N-acetylcysteine in patients with chronic renal failure

P. G. Morgan*, M. Georghiou, F. Flynn and S. Jaggar

London, UK

* E-mail: patgmorgan@hotmail.com

The first 10% of the full text of this article appears below.

Editor—We read with interest the paper by Ristikankare and colleagues1 regarding the lack of renoprotective effect of N-acetylcysteine (NAC) in patients with pre-existing renal failure undergoing cardiac surgery. We feel that several aspects of this study require further comment. First, a recent meta-analysis of the use of NAC to prevent contrast-induced nephropathy in patients with renal impairment was inconclusive,2 therefore, reducing the evidence base for the rational use of NAC. We would also wish to question the inclusion of patients with plasma creatinine greater than 100 µmol litre–1, which is below the upper limit of . . . [Full Text of this Article]

A. Ristikankare*, T. Kuitunen, A. Kuitunen, L. Uotila, A. Vento, R. Suojaranta-Ylinen, M. Salmenperä and R. Pöyhiä

Helsinki, Finland

* E-mail: anne.ristikankare@hus.fi


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