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Sevoflurane analgesia in labour (Sevonox)
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This issue of the British Journal of Anaesthesia sees the publication of two studies of the analgesic effects of sevoflurane in oxygen-enriched air during labour.1 2 The first study determines the optimum concentration of sevoflurane and the second compares this concentration with the current standard inhalation analgesic used during labour, 50% nitrous oxide in 50% oxygen, Entonox®.
The use of volatile agents to provide analgesia during labour dates back to James Young Simpson in 1847. A variety of volatile agents, ether, chloroform, trilene, methoxyflurane, isoflurane and desflurane have all been tried and gradually discarded or replaced. Nitrous oxide has stood the test of time and has been in use in
Edinburgh, UK
E-mail: john.mcclure@ed.ac.uk
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