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Etomidate and fatal outcomeeven a single bolus dose may be detrimental for some patients
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EditorEtomidate has been used for over a quarter of a century in many countries in a variety of anaesthetic and non-anaesthetic settings. Despite problems such as pain on injection, thrombophlebitis and myoclonus, the positive pharmacologic attributes of etomidate have contributed to its continued use. The effect on cardiac output and myocardial oxygenation and its wide therapeutic index, which is approximately 6-fold better than thiopental and propofol, have logically
Aberdeen, UK
*E-mail: d.noble@nhs.net
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