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British Journal of Anaesthesia 2005 95(2):119-121; doi:10.1093/bja/aei159
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions@oupjournals.org

EDITORIAL

Editorial I: The new age of medical genomics

D. A. Schwinn* and M. Podgoreanu

Departments of Anesthesiology, Pharmacology/Cancer Biology, and Surgery, Duke University Medical Center, Durham, NC 27710, USA

* E-mail: Schwi001@mc.duke.edu

The first 10% of the full text of this article appears below.

"I would have everie man write what he knowes and no more."—Montaigne

Genomic tools have enhanced research across all of medicine, including anaesthesia. Our understanding of both acute responses of the heart (such as myocardial preconditioning, ischaemia–reperfusion, stunning and infarction), as well as the onset and development of chronic heart disease, is undergoing a paradigm shift as functional genomic and proteomic research is providing further insights into the complex dynamic regulation of myocardial gene interactions and pathways. In this issue of the British Journal of Anaesthesia, Lucchinetti and colleagues1 demonstrate the use of genome-based technologies to discover mechanisms underlying important clinical questions such as how best to protect the heart in settings of ischaemia. One protective strategy is ischaemic preconditioning, defined as a brief period of controlled ischaemia followed by reperfusion prior to a longer period of . . . [Full Text of this Article]


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