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British Journal of Anaesthesia 2005 94(6):699-701; doi:10.1093/bja/aei128
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions@oupjournals.org

Pumphead—or not! Does avoiding cardiopulmonary bypass for coronary artery bypass surgery result in less brain damage?

R. Peter Alston

Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA UK

E-mail: Peter.Alston@ed.ac.uk

The first 10% of the full text of this article appears below.

Symptomatic benefit aside, coronary artery bypass grafting (CABG) surgery has prognostic advantages. Every day around the world, and despite the inexorable rise in the use of angioplasty, many thousands of patients still have patterns of coronary artery disease that require them to undergo CABG surgery to improve their longevity. However, this success of CABG surgery continues to be marred by a number of serious complications, in particular brain damage.

The most overt manifestation of brain damage is stroke, which fortunately, given its impact on quality of life, occurs infrequently, in ~3% of patients.1 If looked for prospectively, more subtle neurological deficits occur far more frequently, in ~20% of patients.2 3 Cognitive decrements are another manifestation; 19–26% of patients undergoing conventional CABG surgery will experience permanent decrements and the incidence increases with increasing age.3–5 These decrements are important as they affect memory, . . . [Full Text of this Article]

Historical background

OPCAB and stroke

OPCAB and cognition

Cerebral hypoperfusion

Limitations of <50%

Conclusion


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D. van Dijk, J. C. Diephuis, A. P. Nierich, A. M. A. Keizer, and C. J. Kalkman
Beating heart versus conventional cardiopulmonary bypass: the octopus experience: a randomized comparison of 281 patients undergoing coronary artery bypass surgery with or without cardiopulmonary bypass.
Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2006; 10(2): 167 - 170.
[Abstract] [PDF]