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British Journal of Anaesthesia 2005 94(1):3-6; doi:10.1093/bja/aei287
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2005

Editorial II: Opioids and the neuroimmune axis

J. P. Williams and D. G. Lambert*

University Department of Cardiovascular Sciences (Pharmacology and Therapeutics Group), Division of Anaesthesia, Critical Care and Pain Management, LRI, Leicester LE1 5WW, UK

* Corresponding author. E-mail: dgl3@le.ac.uk

The first 150 words of the full text of this article appear below.

In 1998, this journal published an editorial exploring the connection between opioids and the immune system.1 In the intervening 6 yr, our understanding of the peripheral actions of the neuroimmune system has progressed markedly.2 3 The group of Christoph Stein at the Freie Universität, Berlin has been instrumental in the use of basic science approaches to produce a working mechanistic model for potential evaluation in man. Using an inflammatory model in the Wistar rat, a number of pioneering studies4 5 have described the ability of (i) the immune system to deliver endogenous opioids,6 and (ii) inflammation to stimulate delivery of opioid receptors to the site of insult, and hence produce a degree of antinociception.7

When rats are killed up to 24 h after an injection of Freund's complete adjuvant into a hind paw (which produces a local inflammatory response), these animals show an increased expression of mu-opioid receptors in the ipsilateral . . . [Full Text of this Article]


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J. P. Williams, J. P. Thompson, J. McDonald, T. A. Barnes, T. Cote, D. J. Rowbotham, and D. G. Lambert
Human Peripheral Blood Mononuclear Cells Express Nociceptin/Orphanin FQ, but Not {micro}, {delta}, or {kappa} Opioid Receptors
Anesth. Analg., October 1, 2007; 105(4): 998 - 1005.
[Abstract] [Full Text] [PDF]

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Opioids and the neuroimmune axis
Michal R. Pijak
British Journal of Anaesthesia, 24 May 2005 [Full text]