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British Journal of Anaesthesia, 2004, Vol. 92, No. 6 783-784
© 2004 The Board of Management and Trustees of the British Journal of Anaesthesia

Editorial I

Powerful tools require careful handling—the case of the circadian ketamine effect

M. E. Durieux

Department of Anesthesiology, University of Virginia, PO Box 800710, Charlottesville, VA, 22908-0710, USA E-mail: durieux@virginia.edu

The first 10% of the full text of this article appears below.

Circadian rhythms deeply affect our lives: our general energy level and ability to perform exacting work are profoundly affected by the time of day, to the point where the impact of irregular work hours on ability to safely deliver anaesthesia or perform surgery are a matter of concern.1 Circadian changes in hormone levels drive fluctuations in functioning of our bodily systems, and chronobiology, the study of such rhythms, shows that almost every organ system is affected. It is no surprise, therefore, that both the pharmacokinetics and pharmacodynamics of drugs can be influenced by the time of . . . [Full Text of this Article]


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