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British Journal of Anaesthesia, 2001, Vol. 87, No. 6 811-813
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Editorial

Editorial I

Central noradrenergic neurones and the mechanism of general anaesthesia

K. Hirota and T. Kushikata

Modern anaesthetics are, in the main, safe and predictable in their use, and highly efficient. Moreover, it could be argued that without these properties major advances in surgical practice, so often highlighted in the media, could not have taken place. However, as an example of pharmacology, the production of the anaesthetic state remains somewhat of a mystery. This mystery results from the controversies related to the existence of a unitary anaesthetic target site. From direct observation of clinical anaesthesia, this seems unlikely as different anaesthetic agents produce different ‘types’ of anaesthesia. GABAA receptors have long been held as a unifying cellular target (with some exceptions), but others have also been suggested. In this editorial, we . . . [Full Text of this Article]

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R. Tose, T. Kushikata, H. Yoshida, M. Kudo, K. Furukawa, S. Ueno, and K. Hirota
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[Abstract] [Full Text] [PDF]