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British Journal of Anaesthesia, 2001, Vol. 86, No. 3 329-321
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Editorial

Editorial II

Codeine phosphate in children: time for re-evaluation?

M. Cunliffe

Codeine is a well-established drug in the pain armamentarium. It is classed as a ‘weak opioid’ and used to treat pain of mild to moderate severity, either alone or in conjunction with non-opioids. Its route of administration is usually oral or intramuscular (i.m.), although there is a growing interest in using the rectal route in children, from where it is rapidly absorbed, achieving a peak plasma concentration in 30–60 min.1 In this recent study, a dose of codeine 1 mg kg–1 given either rectally or i.m. in children over 3 months old produced a peak codeine level at 30 min, but with a consistently lower plasma level when given rectally. The lower plasma level after rectal administration reflects the reduced bioavailability of the drug when . . . [Full Text of this Article]

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