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British Journal of Anaesthesia, 2001, Vol. 86, No. 1 1-3
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Editorial

Editorial I

Can we characterize the central nervous system actions of {alpha}2-adrenergic agonists?

M. E. P. Jones and M. Maze

Resurgence in interest in {alpha}2-adrenergic agonists has been fuelled by the emergence of dexmedetomidine, the latest {alpha}2-agonist to be developed. Recently licensed in the USA, it has prompted many to re-examine more closely the workings of this fascinating class of drug and thereby its clinical applications. Clonidine, the prototype {alpha}2-agonist, was originally developed in the early 1970s for its potential use as a nasal decongestant. It rapidly found favour as a useful anti-hypertensive agent;1 however, with the advent of the ACE inhibitors and more selective ß-adrenergic antagonists, clonidine has been relegated to no better than a third line alternative for this purpose. It has, however, remained an intriguing compound that has been shown to be efficacious in a wide range of applications, from analgesia,2 sedation and reduction in post-operative shivering,3 to the control of symptoms during alcohol4 and nicotine5 withdrawal. In this issue of the journal, Hall and colleagues report . . . [Full Text of this Article]

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