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British Journal of Anaesthesia 2009 102(4):439-441; doi:10.1093/bja/aep036
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© The Author [2009]. Published by Oxford University Press on behalf of The Board of Directors of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournal.org

Intra-articular bupivacaine: potentially chondrotoxic?

The first 10% of the full text of this article appears below.

The management of acute postoperative pain after orthopaedic surgery is a challenge for anaesthetists and surgeons. The administration of local anaesthetic drugs into the joint space, either by single injection or by continuous infusion, has become a well-recognized technique for postoperative analgesia, in particular after arthroscopic surgery. Bupivacaine is commonly used for intra-articular analgesia because of its long duration of action. Other local anaesthetics used for intra-articular analgesia include ropivacaine and lidocaine. Intra-articular use of these drugs has been widely regarded as safe, and adverse effects of local anaesthetic agents in the joint space have been reported only rarely. Peak plasma concentrations of bupivacaine . . . [Full Text of this Article]

S. T. Webb* and S. Ghosh

Department of Anaesthesia and Intensive Care
Papworth Hospital NHS Foundation Trust
Cambridge
UK

* E-mail: stephen.webb@papworth.nhs.uk


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This article has been cited by other articles:


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 Br J AnaesthHome page
S. M. White, R. Turner, A. F. McNaught, C. McCartney, S. T. Webb, and S. Ghosh
Bupivacaine chondrotoxicity
Br. J. Anaesth., July 1, 2009; 103(1): 133 - 134.
[Full Text] [PDF]

E-letters:

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Avoid intra-articular catheters for continuous infusion of local anaesthetics
André Gottschalk
British Journal of Anaesthesia, 1 Apr 2009 [Full text]
Response to Dr Gottschalk's e-letter
Stephen T Webb, et al.
British Journal of Anaesthesia, 14 Apr 2009 [Full text]
Bupivacaine chondrotoxicity – a role for intra-articular magnesium?
Stuart M. White, et al.
British Journal of Anaesthesia, 16 Apr 2009 [Full text]
Let’s not forget peripheral nerve blocks.
Andrew F McNaught, et al.
British Journal of Anaesthesia, 21 Apr 2009 [Full text]
Response to Drs White & Turner and Drs McNaught & McCartney
Stephen T Webb, et al.
British Journal of Anaesthesia, 7 May 2009 [Full text]