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British Journal of Anaesthesia 2008 101(5):595-596; doi:10.1093/bja/aen292
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Validity, credibility, and applicability: the rise and rise of the surrogate

The first 10% of the full text of this article appears below.

The elusiveness of outcome data of direct relevance to patients makes research in anaesthesia, pain, and critical care a challenge. Surrogate measures are used for several reasons. Instead of measuring the risk of organ injury, death, or long-term personality change after surgery and anaesthesia, we often measure arterial pressure,1 partial pressure of carbon dioxide, hospital stay, or short-term cognitive performance. Is the use of such proxy outcome measures justified? In modelling research, we often turn to physical or theoretical models, generating a single, idealized or ‘typical’ subject upon which to experiment. Is such substitution of reality with simulation reasonable? In basic science, the individual components of physiology or pharmacology are studied in relative isolation. Is it . . . [Full Text of this Article]

J. G. Hardman*, I. K. Moppett and R. P. Mahajan

University Department of Anaesthesia
Queen's Medical Centre
Nottingham NG7 2UH
UK

* E-mail: j.hardman@nottingham.ac.uk


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