BJA Advance Access first published online on August 23, 2008
This version published online on August 29, 2008
British Journal of Anaesthesia, doi:10.1093/bja/aen248
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Morphine pharmacokinetics and pharmacodynamics in preterm and term neonates: secondary results from the NEOPAIN trial
1 Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
2 Division of Anaesthesiology
3 Division of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand
4 University of North Carolina at Chapel Hill and Wake Medical Center, Raleigh, NC, USA
5 Tufts University School of Medicine, Boston, MA, USA
6 University of Kentucky Medical Center, Lexington, KY, USA
7 Maryland Medical Research Institute, Baltimore, MD, USA
* Corresponding author: Arkansas Children's Hospital, Rm S-4417, 800 Marshall Street, Slot 900, Little Rock, AR 72202, USA. E-mail: anandsunny{at}uams.edu
Background: Relationships between plasma morphine concentrations and neonatal responses to endotracheal tube (ETT) suctioning are unknown in preterm neonates.
Methods: Ventilated preterm neonates (n=898) from 16 centres were randomly assigned to placebo (n=449) or morphine (n=449). After an i.v. loading dose (100 µg kg–1), morphine infusions [23–26 weeks postmenstrual age (PMA) 10 µg kg–1 h–1; 27–29 weeks 20 µg kg–1 h–1; and 30–32 weeks 30 µg kg–1 h–1] were established for a maximum of 14 days. Open-label morphine (20–100 µg kg–1) was given for pain or agitation. Morphine assay and neonatal response to ETT suctioning was measured at 20–28 and 70–76 h after starting the drug infusion and at 10–14 h after discontinuation of the study drug. The concentration–effect response was investigated using non-linear mixed effects models.
Results: A total of 5119 data points (1598 measured morphine concentrations and 3521 effect measures) were available from 875 neonates for analysis. Clearance was 50% that of the mature value at 54.2 weeks PMA (CLmat50) and increased from 2.05 litre h–1 70 kg–1 at 24 weeks PMA to 6.04 litre h–1 70 kg–1 at 32 weeks PMA. The volume of distribution in preterm neonates was 190 litre 70 kg–1 (CV 51%) and did not change with age. There was no relationship between morphine concentrations (range 0–440 µg litre–1) and heart rate changes associated with ETT suctioning or with the Premature Infant Pain Profile.
Conclusions: A sigmoid curve describing maturation of morphine clearance is moved to the right in preterm neonates and volume of distribution is increased compared with term neonates. Morphine does not alter the neonatal response to ETT suctioning.
Keywords: anaesthesia, paediatric; anaesthetic–analgesic regimens; analgesics opioid, morphine; model, pharmacodynamic; model, pharmacokinetic
This is a new version as there was an error in the first paragraph of the ‘Age-related changes’ section of the Methods.