Skip Navigation


BJA Advance Access originally published online on June 4, 2008
British Journal of Anaesthesia 2008 101(2):239-243; doi:10.1093/bja/aen153
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
101/2/239    most recent
aen153v1
Right arrow E-Letters: Submit a response to the article
Right arrow E-letters: View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Machata, A.-M.
Right arrow Articles by Marhofer, P.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Machata, A.-M.
Right arrow Articles by Marhofer, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Propofol-based sedation regimen for infants and children undergoing ambulatory magnetic resonance imaging

A.-M. Machata*, H. Willschke, B. Kabon, S. C. Kettner and P. Marhofer

Department of Anaesthesia, General Intensive Care and Pain Therapy, Medical University of Vienna, General Hospital, Waehringer Guertel 18-20, A-1090 Vienna, Austria

* Corresponding author. E-mail: anette-marie.machata{at}meduniwien.ac.at

Background: Propofol is widely used for infants and children requiring sedation for magnetic resonance imaging. However, increased doses of propofol may quickly lead to an unintended deep sedation and respiratory depression. Thus, an appropriate low dosage, which nevertheless ensures sufficient sleep for successful magnetic resonance imaging (MRI) completion, would probably minimize respiratory adverse events. We investigated the safety and efficacy of a low-dose propofol-based sedation regimen in a broad age range of children.

Methods: We investigated 500 infants and children, prospectively. Premedication consisted of i.v. midazolam 0.1 mg kg–1. Sedation was induced with i.v. nalbuphine 0.1 mg kg–1 and propofol 1 mg kg–1, and maintained with propofol 5 mg kg–1 h–1. Outcome measures were induction time, sedation time, recovery time, need for additional sedation, respiratory events, cardiovascular events, paradoxical reactions, and sedation failure.

Results: Data were obtained from 53 infants and 447 children. Median (IQR) age was 5.3 (4.5, 6.1) yr and body weight was 19.3 (16.5, 24.7) kg. The induction time was 2 (1, 2) min, sedation time 55 (45, 65) min, and recovery time 8 (8, 9) min. Additional sedation was necessary in 11 patients (2.2%), mild respiratory events occurred in five patients (1%). All MRI examinations could be completed without paradoxical reaction or sedation failure.

Conclusion: This sedation regimen provides the shortest induction time so far described, a rare demand for additional sedation, a low incidence of respiratory events, and a rapid recovery.

Keywords: anaesthesia, paediatric; anaesthetic techniques, i.v. bolus; anaesthetics i.v., propofol; brain, magnetic resonance imaging; sedation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


E-letters:

Read all E-letters

Propofol for MRI Sedation: The Ideal Anesthetic!
Alan Bielsky, et al.
British Journal of Anaesthesia, 20 Jul 2008 [Full text]

Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.