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BJA Advance Access published online on June 3, 2008
British Journal of Anaesthesia, doi:10.1093/bja/aen129
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Influence of the anaesthetic depth on the inhibition of the oculocardiac reflex during sevoflurane anaesthesia for paediatric strabismus surgery

C. Yi and D. Jee*

Department of Anaesthesiology and Pain Medicine, Yeungnam University College of Medicine, Daemyung-Dong, Nam-Gu, Daegu 705-035, Republic of Korea

* Corresponding author. E-mail: djee{at}med.yu.ac.kr

Background: It remains controversial whether the anaesthetic depth as assessed by bispectral index (BIS) influences the oculocardiac reflex (OCR) during strabismus surgery. We investigated whether BIS-guided sevoflurane titration may help to optimize the anaesthetic depth for inhibition of the OCR during paediatric strabismus surgery.

Methods: Eighty-four patients (aged 2–12 yr) undergoing strabismus surgery were randomly allocated to one of the three groups (n=28 for each) according to target BIS value of 40, 50, and 60. The end-tidal sevoflurane concentration with 50% N2O/O2 was adjusted towards target BIS. The incidence of OCR and the lowest heart rate (HR) were recorded in relation to the end-tidal sevoflurane concentration.

Results: The incidence of OCR was higher in Group BIS-60 (71.4%) than in Groups BIS-40 (10.7%) (P<0.001) or BIS-50 (32.1%) (P=0.003), with no difference between Group BIS-40 and Group BIS-50. The lowest HR [beats min–1, mean (SD)] during traction on the extraocular muscle was lower in Group BIS-60 [112.3 (SD 17.8)] compared with Group BIS-40 [129.3 (11.2)] (P<0.001), with no difference between BIS-40 and BIS-50 [121.4 (16.3)], and between BIS-50 and BIS-60. The end-tidal sevoflurane concentration was different between the three groups (P=0.001).

Conclusions: We confirmed that OCR is relevant to the depth of anaesthesia. BIS values of 40–50 seem adequate for the inhibition of OCR. The results suggest that BIS may be a valuable tool during sevoflurane anaesthesia for strabismus surgery in children.

Keywords: anaesthesia, depth; anaesthesia, paediatric; anaesthetics volatile, sevoflurane; monitoring, bispectral index; strabismus


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