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BJA Advance Access originally published online on October 23, 2007
British Journal of Anaesthesia 2007 99(6):787-793; doi:10.1093/bja/aem292
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Minimum alveolar concentration of halogenated volatile anaesthetics in left ventricular hypertrophy and congestive heart failure in rats

T. Barbry1, M. Le Guen1, V. De Castro1, P. Coriat1, B. Riou1,2 and B. Vivien1,*

1 Laboratoire d’Anesthésiologie (EA 3975), Département d’Anesthésie-Réanimation
2 Service d’Accueil des Urgences, Centre Hospitalier Universitaire Pitié-Salpêtrière, Assistance Publique—Hôpitaux de Paris, Université Pierre et Marie Curie—Paris VI, 47–83 Boulevard de l’Hôpital, 75651 Paris Cedex 13, France

* Corresponding author. Département d’Anesthésie-Réanimation, Centre Hospitalier Universitaire Pitié-Salpêtrière, 47–83 Boulevard de l’Hôpital, 75651 Paris Cedex 13, France. E-mail: benoit.vivien{at}psl.aphp.fr

Background: Although many physiological and pathological conditions affect minimal alveolar concentration (MAC), there are no reliable data on the MAC for halogenated anaesthetics during left ventricular hypertrophy (LVH) and congestive heart failure (CHF). The aim of this experimental study was to determine the MAC values of halothane, isoflurane, and sevoflurane in rats, at early and later stages of cardiomyopathic hypertrophy.

Methods: LVH was induced by ascending aortic stenosis in 3–4-week-old rats. LVH and CHF in each animal were assessed weekly by echocardiography. MAC of halothane, isoflurane, and sevoflurane was determined using the tail-clamp technique in spontaneously breathing rats from each group. Response vs no-response data were analysed using logistic regression analysis. Data are medians (95% confidence interval).

Results: The MAC of halothane [1.30% (1.26–1.34)], isoflurane [1.52% (1.48–1.57)], and sevoflurane [2.93% (2.78–3.07)] in rats with LVH was not different from sham-operated rats [respectively, 1.23% (1.20–1.26), 1.52% (1.47–1.56), and 2.90% (2.79–3.00)]. Conversely, the MAC of halothane [1.44 (1.39–1.50)] and isoflurane [1.74 (1.69–1.78)], but not sevoflurane [2.99 (2.93–3.06)], was significantly increased in rats with CHF.

Conclusions: MAC values for halothane, isoflurane, and sevoflurane were unchanged in rats with pressure-induced overload LVH. Conversely, the MAC for halothane and isoflurane, but not sevoflurane, was significantly increased in rats with CHF.

Keywords: anaesthetics volatile, halothane; anaesthetics volatile isoflurane; anaesthetics volatile, sevaflurane; heart, myocardial function; potency, anaesthetic, MAC


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