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British Journal of Anaesthesia 2007 99(6):775-786; doi:10.1093/bja/aem316
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 BJA: December 2007
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Gabapentin: a multimodal perioperative drug?

V. K. F. Kong and M. G. Irwin*

Department of Anaesthesiology, Queen Mary Hospital, The University of Hong Kong, HKSAR, Hong Kong

* Corresponding author. E-mail: mgirwin{at}hkucc.hku.hk

Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. It was not, until recently, thought to be useful in acute perioperative conditions. However, a growing body of evidence suggests that perioperative administration is efficacious for postoperative analgesia, preoperative anxiolysis, attenuation of the haemodynamic response to laryngoscopy and intubation, and preventing chronic post-surgical pain, postoperative nausea and vomiting, and delirium. This article reviews the clinical trial data describing the efficacy and safety of gabapentin in the setting of perioperative anaesthetic management.

Keywords: analgesics non-opioid, gabapentin; pain, chronic; premedication, anxiolysis; reflexes, laryngeal; vomiting, nausea


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