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BJA Advance Access originally published online on June 6, 2007
British Journal of Anaesthesia 2007 99(1):43-48; doi:10.1093/bja/aem142
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Impact of genetic factors on outcome from brain injury

M. Wilson1,* and H. Montgomery2,3

1 Neurosurgery and Prehospital Care, Royal London Hospital, London E1 1BB, UK
2 Whittington Hospital, London, UK
3 Cardiovascular Genetics and Institute for Human Health and Performance, University College London, London N19 5LW, UK

* Corresponding author. E-mail: mark{at}medicstravel.com

Most human phenotypic characteristics are determined by the interplay of environmental factors (whether external, or related to the internal milieu) with the unique genetic attributes of the individual. The same is true for predisposition to and outcome from most disease states, with acute brain injury being no exception. A greater understanding of this interplay is likely to allow improved risk stratification of patients, the development of new preventative and therapeutic modalities, and the possibility of ‘individualizing’ patient management based upon their genetic inheritance.

Keywords: complications, neurological; genetic factors; head, injury


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