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British Journal of Anaesthesia 2007 99(1):132-138; doi:10.1093/bja/aem144
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Neuromuscular junction in health and disease

N. P. Hirsch*

The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK

* E-mail: nicholas.hirsch{at}uclh.nhs.uk

A number of illnesses and other factors can affect the function of the neuromuscular junction (NMJ). These may have an affect at pre- or post-junctional sites. This review outlines the anatomy and the physiology of the NMJ. It also describes the mechanisms and physiological basis of many of the disorders of the NMJ. Finally, the importance of these disorders in anaesthetic practice is discussed.

Keywords: myasthenia gravis; nerve; transmission


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